Association of Epigenetic Aging with Plasma Biomarkers of Amyloid, Tau, Neurodegeneration and Neuroinflammation in Diverse Hispanic/Latino Adults.
Abstract
Epigenetic clocks are biomarkers of biological age based on DNA methylation (DNAm) patterns and are widely used as predictors of health and aging outcomes. Multiple epigenetic clocks have been developed and reflect different aspects of the multidimensional aging process, above and beyond chronological age. To date, no study has examined the relationship of epigenetic aging with circulating biomarkers of Alzheimer’s Disease (AD). We investigated the association of 6 epigenetic clocks with plasma glial fibrillary acidic protein (GFAP), amyloid beta 40 and 42, phosphorylated tau 181 (p‐tau181), and neurofilament light chain (NfL) in diverse Hispanic/Latino adults.
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Research summary
The paper investigates the association between epigenetic aging and plasma biomarkers related to Alzheimer's Disease, which is a significant age-related condition. While it does not directly address the root causes of aging or lifespan extension, it contributes to understanding biological aging processes and their implications for neurodegeneration. The findings may provide insights into the aging process and its relationship with neurodegenerative diseases, making it a solid piece of research, though its impact is somewhat limited as it primarily correlates existing biomarkers rather than proposing novel interventions or solutions.
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