Discovery of Genes Underlying Cognitive Resilience in Individuals Predisposed to Alzheimer's Disease Risk.

Wei Tsai, Caitlin E. McNiff, Joseph S. Reddy, Xue Wang, Zachary Quicksall, Kwangsik Nho, Amy R Dunn, Mariet Allen, Michael G. Heckman, Yingxue Ren, Na Zhao, Kejal Kantarci, Michelle M. Mielke, Ronald C. Petersen, Catherine C. Kaczorowski, Minerva M. Carrasquillo, Andrew J. Saykin, Nilüfer Ertekin‐Taner

Mayo Clinic, Jacksonville, FL, USA · pubmed

Paper

Abstract

Two main risk factors of Alzheimer’s disease (AD) are aging and APOE‐ε4. However, some individuals remain cognitively normal despite having these risk factors. They are considered “cognitively resilient”. This study aimed to identify molecular factors that confer cognitive resilience in APOE‐ε4 carriers ≥ 80 years of age and may serve as biomarkers.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates cognitive resilience in individuals predisposed to Alzheimer's disease, which is a significant age-related condition. While it identifies molecular factors that may serve as biomarkers, the focus is primarily on understanding resilience rather than addressing the root causes of aging or extending lifespan. Thus, it contributes solid research but has limited impact on the broader field of longevity research.

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