Biological Aging and the Motoric Cognitive Risk Syndrome.

Sanish Sathyan, Hamilton Se‐Hwee Oh, Ayers Emmeline, Jarod Rutledge, Dristi Adhikari, Tina Gao, Sofiya Milman, Tony Wyss‐Coray, Nir Barzilai, Joe Verghese

Albert Einstein College of Medicine, Bronx, NY, USAAlbert Einstein College of Medicine, Bronx, NY, USA · pubmed

Paper

Abstract

Motoric Cognitive Risk (MCR) syndrome is a predementia syndrome characterized by slow gait and subjective cognitive concerns. Individuals with MCR are at high risk of transitioning to both Alzheimer's disease (AD) and vascular dementia. With chronological age, the incidence of MCR increases and MCR cases exhibit a higher prevalence of age‐associated diseases. Biological age reflects an individual's accumulated physiological condition captured by changes at the epigenetic (DNA methylation) as well as proteomic levels (protein expression). Aging varies between individuals and at organ‐specific level within an individual. Our objectives were to (1) examine associations between biological age acceleration and MCR, (2) to identify organs that are aging at faster rate in MCR using novel organ‐specific clocks, and (3) impact of biological aging with mortality in MCR.

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Research summary

The paper addresses the Motoric Cognitive Risk syndrome in relation to biological aging, which is pertinent to understanding aging processes and their implications for age-related diseases. However, it primarily focuses on associations and risk factors rather than addressing root causes of aging or proposing interventions for lifespan extension. The findings may contribute to the field but do not represent a significant advancement or breakthrough.

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