Network‐based Plasma Proteomics Reveals Molecular Overlap Between Physical Activity and Dementia Risk.

Rowan Saloner, Emily W. Paolillo, Claire J. Cadwallader, Anna M. VandeBunte, Coty Chen, Tony Wyss‐Coray, Joel H. Kramer, Kaitlin B. Casaletto

Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA · pubmed

Paper

Abstract

Physical activity (PA) is associated with lower dementia risk; however, underlying molecular pathways are poorly understood. We leveraged large‐scale plasma proteomics to identify biological signatures of objectively‐monitored PA in cognitively unimpaired (CU) older adults and cross‐validated signatures in independent exercise intervention and Alzheimer’s disease (AD) cohorts.

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Research summary

The paper investigates the molecular pathways linking physical activity to dementia risk, which is pertinent to understanding aging and age-related diseases. However, it primarily focuses on correlational findings rather than addressing the root causes of aging or providing solutions for lifespan extension. The research contributes solid insights into the biological mechanisms associated with physical activity and dementia but does not present groundbreaking findings that would significantly advance the field of longevity research.

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