Resting‐state activity across cortical hierarchies provides readiness for memorizing in aging humans.
Abstract
The neural basis of memory aging remains elusive. The default mode network (DMN) supports memory encoding and retrieval, and its connectivity decreases in aging. Young adults with larger differences in resting‐state functional connectivity (rsFC) between higher‐order DMN and lower‐order sensory/motor network (SMN) have better cognition and memory. We combined resting‐state and task‐based fMRI during an associative memory task to explore how this cross‐hierarchical contrast of rsFC is linked to memory aging.
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Research summary
The paper investigates the neural mechanisms underlying memory aging, specifically focusing on the connectivity patterns in the brain that may influence cognitive function in older adults. While it does not directly address the root causes of aging or lifespan extension, it contributes to understanding age-related cognitive decline, which is relevant to longevity research. The findings may provide insights into cognitive resilience in aging, but the impact is limited as it primarily builds on existing knowledge without presenting groundbreaking new concepts.
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