Resting State Functional Connectivity Assessment of Healthy Aging Trajectories in the Marmoset Brain.

Rebecca Bhik‐Ghanie, Diego Szczupak, Bei Zhang, Daniel Papoti, Vinicius Campos, Lauren R Dubberley, T Kevin Hitchens, Fang‐Cheng Yeh, Lauren K Hayrynen Schaeffer, Gregory W Carter, Stacey J Sukoff Rizzo, David J Schaeffer, Afonso C Silva

University of Pittsburgh School of Medicine, Pittsburgh, PA, USA · pubmed

Paper

Abstract

The common marmoset (Callithrix jacchus) is an important animal model in neuroscience and neurological diseases, presenting primate‐specific evolutionary features such as an expanded frontal cortex. We established a new consortium with funding support from the National Institute on Aging to generate, characterize, and validate MArmosets as Research MOdels of AD (MARMO‐AD). This consortium develops and studies gene‐edited marmoset models carrying genetic risk for AD, comparing them against wild‐type aging marmosets from birth throughout their lifespan, using non‐invasive longitudinal assessments. Here, we aim to characterize healthy aging trajectories by investigating their resting state functional connectivity in a population of marmosets.

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Research summary

The paper investigates healthy aging trajectories in marmosets, which is relevant to understanding the biological processes of aging. However, it primarily focuses on functional connectivity and the effects of genetic risk for Alzheimer's disease rather than addressing the root causes of aging or lifespan extension. Thus, while it contributes to the field of aging research, its impact is limited and more incremental than transformative.

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