Senescence‐associated secretory phenotype (SASP) index in individuals across the Alzheimer’s disease continuum.

Alvaro de Oliveira Franco, Thomas Hugentobler Schlickmann, João Pedro Ferrari‐Souza, Marco Antônio de Bastiani, Raphael Machado Castilhos, Eduardo R. Zimmer

Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil · pubmed

Paper

Abstract

Cellular senescence (CS) is a hallmark of aging. Senescence‐associated secretory phenotype (SASP) index was recently developed based on the levels of blood SASP‐related proteins. Although aging is a primary risk factor for Alzheimer's disease (AD), the role of CS in this neurodegenerative condition is not well understood. Here, we investigated the association of the SASP index (SI) with classical markers of AD.

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Research summary

The paper investigates the SASP index in relation to Alzheimer's disease, which is indeed an age-related condition. However, it primarily focuses on the association of SASP with classical markers of AD rather than addressing the root causes of aging or proposing interventions that could extend lifespan or mitigate aging processes. While it contributes to understanding the relationship between cellular senescence and Alzheimer's, its impact is limited as it does not present significant advancements in longevity research.

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