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RESEARCH PAPER / 2025-01-10

The association between a pro‐inflammatory diet and machine learning‐based brain age in middle‐aged and older adults: Findings from the UK Biobank.

Michelle M. Dunk, Huijie Huang, Jiao Wang, Abigail Dove, Sakura Sakakibara, Jie Guo, Adrián Carballo‐Casla, David A. Bennett, Weili Xu

Aging Research Center, Karolinska Institutet, Stockholm, Sweden · pubmed

Abstract

Pro‐inflammatory diets have been associated with cognitive decline and dementia, but their impact on overall brain aging is unclear. We aimed to investigate the relationship between a pro‐inflammatory diet and a machine learning‐based measure of brain age, taking into account age, genetic risk for Alzheimer’s disease (AD), and systemic inflammation.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the association between a pro-inflammatory diet and brain aging, which is relevant to understanding cognitive decline and age-related diseases. However, it primarily focuses on dietary impacts rather than addressing the root causes of aging or lifespan extension. The findings may contribute to the field of aging research but do not represent a significant advancement or breakthrough.

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