Design, Characteristics, and Resources from the Diabetes Prevention Program Outcomes Study (DPPOS) AD/ADRD project.
Abstract
Persons with prediabetes and type 2 diabetes (T2D) are known to have higher risk of cognitive impairment (CI), including age‐related cognitive decline, mild cognitive impairment (MCI), and dementia; however, the characteristics of CI and the determinants and mechanisms in prediabetes and T2D remain unclear. Addressing these gaps is critical since over half of the U.S. population aged 60 years and older, who are at risk for AD/ADRD, have prediabetes or T2D.
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Research summary
The paper addresses the relationship between prediabetes, type 2 diabetes, and cognitive impairment, which are important factors in aging and age-related diseases. However, it primarily focuses on the characteristics and determinants of cognitive impairment rather than addressing the root causes of aging or proposing interventions for lifespan extension. The findings may contribute to understanding cognitive decline in older adults but do not represent a significant advancement in longevity research.
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