Glycoproteome‐wide analyses in the dorsolateral prefrontal cortex identified glycopeptiforms associated with cognitive decline in specific cognitive domains.

Michal S Beeri, Yishai Levin, David Morgenstern, Nili Tikotzki, Hila Levy, Itzik Cooper, Hans‐Ulrich Klein, David A. Bennett, Lei Yu, Aron S Buchman

Herbert and Jackeline Krieger Klein Alzheimer’s Research Center, Rutgers Biomedical and Health Sciences, Newark, NJ, USAHerbert and Jackeline Krieger Klein Alzheimer’s Research Center, Rutgers Biomedical and Health Sciences, Newark, NJ, USA · pubmed

Paper

Abstract

Molecular omics studies of aging brains have identified genes and proteins related to cognitive decline. Identifying proteins that are linked to specific cognitive abilities has potential to catalyze the development of targeted therapies for specific cognitive deficits. Posttranslational modifications of proteins with glycans modify protein function. Here, we identified glycopeptiforms associated with decline in specific cognitive domains.

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Research summary

The paper investigates glycopeptiforms associated with cognitive decline, which is relevant to understanding mechanisms underlying cognitive aging. However, it primarily focuses on identifying proteins linked to cognitive deficits rather than addressing the root causes of aging or developing therapies aimed at lifespan extension. The findings may contribute to the field but do not represent a significant breakthrough or transformative advancement.

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