Higher cardiorespiratory fitness is associated with higher cerebral myelination in normative aging.
Abstract
Age‐related white matter (WM) deterioration has been associated with several neurodegenerative diseases, including Alzheimer’s disease. Studies suggest that cardiorespiratory fitness (CRF) is important in preserving WM structure and function. However, clinical investigations of the relationship between myelin integrity and CRF are lacking. In this study, we evaluated the association between CRF, assessed by the maximum rate of oxygen consumption (VO
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Research summary
The paper investigates the association between cardiorespiratory fitness and cerebral myelination in the context of normative aging, which is relevant to understanding mechanisms that may influence longevity and age-related cognitive decline. However, the findings appear to be more incremental rather than groundbreaking, as they primarily reinforce existing knowledge about the benefits of physical fitness on brain health without addressing root causes of aging or proposing novel interventions.
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