KLOTHO‐VS heterozygosity ameliorates the effects of APOE ε4 on longitudinal hippocampal atrophy.

Linda Zhang, Eva Alfayate, Miguel Calero, Miguel Medina, Michel J. Grothe, Pascual Sanchez‐Juan, Bryan A. Strange

Reina Sofia Alzheimer Centre, CIEN Foundation, ISCIII, Madrid, Spain · pubmed

Abstract

KLOTHO‐VS heterozygosity (KL‐VS

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Research summary

The paper investigates the genetic factors associated with KLOTHO‐VS heterozygosity and its effects on hippocampal atrophy in the context of APOE ε4, which is linked to Alzheimer's disease. While it addresses a genetic aspect that may influence aging-related cognitive decline, it primarily focuses on a specific disease rather than addressing the root causes of aging or lifespan extension. Thus, it contributes solid research but has limited impact on the broader field of longevity.

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