The role of sex in the association between peripheral insulin and cortical thickness in cognitively intact older adults by amyloid status.

Amaryllis A Tsiknia, Meral A Tubi, Noelle Lee, Brandon J Hall, Melissa Petersen, Stephanie E Large, Arthur W. Toga, Sid E. O'Bryant, Kristine Yaffe, Meredith N Braskie

Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA · pubmed

Paper

Abstract

Compared to men, insulin‐resistant women have more brain atrophy, cognitive impairment, and higher dementia risk, but the mechanisms for this sex difference are unknown. We examined sex differences in how blood insulin relates to cortical thickness in cognitively intact older adults. Gaining a better understanding of the relationship between insulin and brain health could help inform the development of insulin‐targeting treatments and reduce the risk of dementia associated with insulin resistance.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the relationship between insulin resistance and brain health, specifically focusing on sex differences in older adults. While it addresses an important aspect of aging and cognitive decline, it primarily explores associations rather than targeting root causes of aging or proposing interventions that could extend lifespan. The findings may contribute to understanding dementia risk but do not significantly advance the field of longevity research. Thus, it is rated as a solid research contribution with limited impact.

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