Interrelationship between perivascular spaces and white matter hyperintensities: A latent growth curve analysis.

Inga Menze, Jose Bernal Moyano, Pinar Kaya, Cagla Aki, Malte Pfister, Jonas Geisendörfer, Renat Yakupov, Roberto Duarte, Maria del C. Valdes Hernandez, Michael T. Heneka, Frederic Brosseron, Matthias Schmid, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Ayda Rostamzadeh, Dix U. Meiberth, Oliver Peters, Lukas Preis, Dominik Lammerding, Daria Gref, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Andrea Lohse, Stefan Hetzer, Anja Schneider, Klaus Fliessbach, Okka Kimmich, Ina R Vogt, Jens Wiltfang, Claudia Bartels, Björn H. Schott, Niels Hansen, Peter Dechent, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris‐Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H. J. Munk, Carolin Sanzenbacher, Petra Hinderer, Klaus Scheffler, Annika Spottke, Nina Roy‐Kluth, Falk Lüsebrink, Katja Neumann, Joanna M Wardlaw, Frank Jessen, Stefanie Schreiber, Emrah Düzel, Gabriel Ziegler

German Center for Neurodegenerative Diseases (DZNE), Magdeburg, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany · pubmed

Paper

Abstract

Inadequate glymphatic clearance through perivascular spaces (PVS) is hypothesized to contribute to the formation of white matter hyperintensities (WMH). However, longitudinal evidence for such a mechanistic link in aging remains limited. Using multivariate modelling, we investigated the interrelationship between PVS and WMH over time to elucidate potential cascades of early cerebrovascular alterations and tested whether AD‐biomarkers and inflammatory markers associated with vascular disease can explain individual variability in their occurrence and progression.

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Research summary

The paper investigates the relationship between perivascular spaces and white matter hyperintensities, which are relevant to cerebrovascular health in aging. However, it primarily focuses on correlational aspects and does not address root causes of aging or propose mechanisms for lifespan extension. The findings may contribute to understanding age-related changes but do not represent a significant advancement in longevity research.

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