Fitness, gray matter volume, and executive function in cognitively normal older adults: cross‐sectional findings from the AGUEDA trial.

Andrea Coca‐Pulido, Patricio Solis‐Urra, Beatriz Fernandez‐Gamez, Marcos Olvera‐Rojas, Dario Bellon, Alessandro Sclafani, Angel Toval, Isabel Martin‐Fuentes, Esmée A Bakker, Javier Fernandez‐Ortega, Manuel Gomez‐Rio, Charles Hillman, Kirk I. Erickson, Francisco B Ortega, Jose Mora‐Gonzalez, Irene Esteban‐Cornejo

Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada., Granada, Granada, SpainFaculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada., Granada, Granada, Spain · pubmed

Paper

Abstract

Understanding the association of different fitness components with brain structure, and further, how possible fitness‐related brain associations relate to executive function is important for developing public health strategies to improve the health and wellbeing of elderly adults worldwide. Thus, we aimed to investigate the association of cardiorespiratory fitness (CRF) and muscular strength measures with gray matter volume (GMV), and to study whether fitness‐related regions of GMV are associated to executive function (EF) in cognitively normal older adults.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the relationship between fitness components, brain structure, and executive function in cognitively normal older adults, which is relevant to understanding factors that may influence healthy aging. However, the findings appear to be more focused on associations rather than addressing root causes of aging or lifespan extension. Thus, while it contributes to the field of aging research, its impact is limited and more incremental than groundbreaking.

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