APOE genotype, polygenic risk for Alzheimer’s disease, and plasma cytokines in participants of the multisite SuperAging Research Initiative.

Matt Huentelman, Ignazio Piras, Marcus Naymik, Bobbi Stark, Anna Bonfitto, Francis Taguinod, Rhiana Schafer, Adam Martersteck, Amanda Cook Maher, Changiz Geula, Emily J Rogalski

The Translational Genomics Research Institute (TGen‐ an Affiliate of City of Hope), Phoenix, AZ, USAThe Translational Genomics Research Institute (TGen‐ an Affiliate of City of Hope), Phoenix, AZ, USA · pubmed

Paper

Abstract

The SuperAging Research Initiative (SRI) seeks to identify factors that promote cognitive healthspan. SuperAgers are defined as individuals aged 80 and older with episodic memory performance that is at least average for people who are two to three decades younger. A goal of the SRI is to identify the genomic contributors to SuperAging and herein we describe the interim results of DNA‐ and plasma protein‐based analyses.

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Research summary

The paper investigates genetic and plasma protein factors associated with cognitive healthspan in older adults, specifically focusing on SuperAgers. While it addresses aspects of aging and cognitive health, it primarily examines correlational factors rather than targeting the root causes of aging or proposing interventions for lifespan extension. Thus, it contributes solid research but has limited impact on the broader field of longevity research.

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