Using fixel‐based analysis to understand the role of crossing fibers in age‐related white matter decline.

Aditi Sathe, Niranjana Shashikumar, Elizabeth E. Moore, Kimberly R. Pechman, Kurt Schilling, Bennett A. Landman, Katherine A. Gifford, Andrew R. Bender, Timothy J. Hohman, Angela L. Jefferson, Derek B. Archer

Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA · pubmed

Paper

Abstract

Aging is linked to significant white matter abnormalities, which are often studied using traditional diffusion tensor imaging (DTI) metrics; however, these traditional metrics have limited sensitivity/specificity to neurobiological characteristics. Here, we use fixel‐based analysis (FBA) – an approach with more precision in areas of crossing fibers – to study age‐related white matter microstructural decline.

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Research summary

The paper investigates age-related white matter decline using a more precise imaging technique, which contributes to understanding the biological changes associated with aging. However, it does not address the root causes of aging or propose solutions for lifespan extension, limiting its overall impact on the field of longevity research. The findings may be solid but are more incremental in nature rather than transformative.

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