Biological aging is associated with atypical neurodegenerative patterns in Alzheimer's disease.
Abstract
Atypical presentations of Alzheimer’s disease (AD), which demonstrate more cortical involvement relative to medial temporal lobe (MTL), are generally associated with younger age of onset. Age, defined chronologically, is a primary driver of AD pathology and neurodegeneration. However, some young onset cases are typical, amnestic presentations and some older onset cases present more cortical atrophy. We hypothesize that a biological definition of age, defined using epigenetic clock measures, may be even more tightly linked to atypicality than chronological age.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper explores the relationship between biological aging, as measured by epigenetic clocks, and atypical neurodegenerative patterns in Alzheimer's disease. While it addresses an important aspect of aging and its implications for neurodegeneration, the focus remains on characterizing disease presentations rather than directly addressing the root causes of aging or proposing interventions for lifespan extension. Thus, it contributes solid research but with limited impact on the broader field of longevity.
Author of this paper? Send a correction.