Limited restoration of T cell subset distribution and immune function in older people living with HIV-1 receiving HAART.

Na Li, Hong-Yi Zheng, Wei Li, Xiao-Yan He, Mi Zhang, Xia Li, Ren-Rong Tian, Xing-Qi Dong, Zhi-Qiang Shen, Yong-Tang Zheng

School of Pharmaceutical Sciences, Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, China. · pubmed

Paper

Abstract

Older people living with HIV-1 (PLWH) experience a dual burden from the combined effects of aging and HIV-1 infection, resulting in significant immune dysfunction. Despite receiving HAART, immune reconstitution is not fully optimized. The objective of this study was to investigate the impact of aging and HAART on T cell subsets and function in PLWH across different age groups, thereby providing novel insights into the prognosis of older PLWH.

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Research summary

The paper addresses the immune dysfunction experienced by older individuals living with HIV-1, which is relevant to the broader context of aging and age-related diseases. However, it primarily focuses on the effects of HAART on T cell subsets rather than addressing the root causes of aging or proposing solutions for lifespan extension. The findings contribute to our understanding of immune reconstitution in older PLWH but do not present significant advancements that would have a major impact on the field of longevity research.

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