Shift work schedules alter immune cell regulation and accelerate cognitive impairment during aging.

Karienn A de Souza, Morgan Jackson, Justin Chen, Jocelin Reyes, Judy Muayad, Emma Tran, William Jackson, M Karen Newell-Rogers, David J Earnest

Department of Neuroscience and Experimental Therapeutics, School of Medicine, Texas A&M Health Science Center, Bryan, TX, 77807-3260, USA. [email protected]. · pubmed

Paper

Abstract

Disturbances of the sleep-wake cycle and other circadian rhythms typically precede the age-related deficits in learning and memory, suggesting that these alterations in circadian timekeeping may contribute to the progressive cognitive decline during aging. The present study examined the role of immune cell activation and inflammation in the link between circadian rhythm dysregulation and cognitive impairment in aging.

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Research summary

The paper investigates the relationship between circadian rhythm dysregulation and cognitive impairment in aging, focusing on immune cell activation and inflammation. While it addresses factors that may contribute to cognitive decline, it does not directly target the root causes of aging or propose mechanisms for lifespan extension. The findings may provide insights into age-related cognitive decline, but the overall impact on longevity research is limited.

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