Long-term intake of Tamogi-take mushroom (Pleurotus cornucopiae) mitigates age-related cardiovascular dysfunction and extends healthy life expectancy.

Michio Sato, Daisuke Torigoe, Yuya Kinoshita, Momoka Cyuman, Chitoku Toda, Masaru Sato, Kazutaka Ikeda, Tsuyoshi Kadomatsu, Haruki Horiguchi, Jun Morinaga, Hirotaka Fukami, Taichi Sugizaki, Keishi Miyata, Ryoko Kusaba, Yusuke Okadome, Eiji Matsunaga, Koichi Node, Yuichi Oike

Department of Molecular Genetics, Kumamoto University, Kumamoto, Japan.Department of Molecular Genetics, Kumamoto University, Kumamoto, Japan. · pubmed

Paper

Abstract

Age-related declines in cardiac function and exercise tolerance interfere with healthy living and decrease healthy life expectancy in older individuals. Tamogi-take mushrooms (Pleurotus cornucopiae) are known to contain high levels of Ergothioneine (EGT), an antioxidant with potential health benefits. In this study, we assessed the possibility that long-term consumption of Tamogi-take mushrooms might attenuate age-related decline in cardiac and vascular endothelial function in mice. We found that long-term intake of Tamogi-take mushrooms significantly maintained cardiac and vascular endothelial function and improved exercise tolerance in mice. Long-term mushroom consumption also increased levels of Nrf2 (Nuclear factor E2-related factor 2) protein in heart tissues and increased translation of HO-1 (Heme Oxygenase 1) proteins, which have antioxidant effects in heart and aortic tissues. Finally, long-term Tamogi-take mushroom consumption inhibited ROS accumulation with aging and reduced expression of inflammatory biomarkers. We conclude that ingestion of Tamogi-take mushrooms could serve as a dietary intervention to promote cardiovascular health, support healthy aging and slow the progression of age-related diseases.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the long-term effects of Tamogi-take mushrooms on age-related cardiovascular dysfunction, which is directly related to healthy aging and longevity. It explores mechanisms such as antioxidant effects and inflammation reduction, contributing to the understanding of dietary interventions in aging. However, while the findings are solid, they represent a limited advance in the broader field of longevity research, hence the moderate impact score.

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