Associations between physical activity, brain health, cognitive function, and circulating GPLD1 in healthy older (65-85 years) individuals.

Kara L Marlatt, Adam C Lowe, Guillermo Sanchez-Delgado, Robbie A Beyl, Matthew K Viverito, Jeffrey N Keller, Owen T Carmichael, Eric Ravussin

Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA. · pubmed

Paper

Abstract

Declines in physical and cognitive function are common in older adults. The circulating enzyme glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (GPLD1) is elevated after exercise and has been associated with improved cognitive function when administered to aged mice. The purpose of this study was to investigate the relationship between GPLD1 and both cognitive function and brain structure/function in older adults with either high or low levels of physical activity. Healthy men and women aged 65 to 85 years with a body mass index between 20 and 35 kg/m

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Research summary

The paper investigates the relationship between physical activity, brain health, and cognitive function in older adults, which is pertinent to understanding factors that may influence longevity and healthy aging. However, the focus on circulating GPLD1 and its association with cognitive function appears to be more of an incremental advance rather than a transformative finding. The study does not address root causes of aging or lifespan extension directly, limiting its overall impact.

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