The effect of conditioned medium from human amniotic membrane-derived mesenchymal stem cells on thymus involution.

Catarina S Silva, Marta R Casanova, Pedro Ferreirinha, Alain da Silva Morais, Hugo Osório, Ana C Lima, Joana F Fangueiro, Mariana T Cerqueira, Rui L Reis, Nuno L Alves, Albino Martins, Nuno M Neves

3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho; Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine; Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory; Braga/Guimarães, Portugal.3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho; Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine; Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory; Braga/Guimarães, Portugal. · pubmed

Paper

Abstract

The development and selection of T cells occur within the thymus. This organ involutes throughout life, compromising the generation of T cells and, consequently, the efficacy of the immune system. Mesenchymal stem cells (MSC) have beneficial effects on the immune system. Therefore, MSC have been applied in different pathologies related with thymic function. However, there is a lack of knowledge on the potential role of MSC-derived secretome on thymus involution. This work aims at studying the effect of human amniotic membrane-derived MSC conditioned media (hAMMSC CM) on aged thymus.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the effect of conditioned medium from human amniotic membrane-derived mesenchymal stem cells on thymus involution in aged individuals. This research is relevant as it explores a potential intervention that could address thymic involution, which is a contributor to immune system decline associated with aging.

Author of this paper? Send a correction.