E-jet printed polycaprolactone with strontium-substituted mesoporous bioactive glass nanoparticles for bone tissue engineering.

Chee Hoe Kong, Chris Steffi, Yanli Cai, Wilson Wang

Department of Orthopaedic Surgery, National University of Singapore, NUHS Tower Block, Level 11, 1E Kent Ridge Road, Singapore 119228, Singapore. Electronic address: [email protected] of Orthopaedic Surgery, National University of Singapore, NUHS Tower Block, Level 11, 1E Kent Ridge Road, Singapore 119228, Singapore. Electronic address: [email protected]. · pubmed

Paper

Abstract

Osteoporosis, characterized by reduced bone mineral density and increased fracture risk, poses a significant health challenge, particularly for aging populations. Systemic treatments often lead to adverse side effects, emphasizing the need for localized solutions. This study introduces a 3D-printed polycaprolactone (PCL) scaffold embedded with strontium-substituted mesoporous bioactive glass nanoparticles (Sr-MBGNPs) and icariin (ICN) for the targeted regeneration of osteoporotic bone. The scaffold was characterized using scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), ion release studies, and cellular assays, which confirmed its dual functionality in both enhancing osteoblast proliferation and differentiation and inhibiting osteoclastogenesis. The optimized Sr-MBGNP concentration ensured sustained ion release, superior hydrophilicity, and bioactivity without compromising scaffold integrity. Additionally, e-jet printing provided high precision and uniform pore sizes conducive to cellular activity. This novel scaffold platform demonstrates a promising localized treatment strategy, reducing systemic side effects while improving fixation stability. The innovative integration of Sr-MBGNPs and ICN highlights its potential to revolutionize osteoporosis therapy by promoting bone regeneration and mitigating bone resorption.

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Research summary

The study claims that a 3D-printed polycaprolactone scaffold embedded with strontium-substituted mesoporous bioactive glass nanoparticles can enhance osteoblast proliferation and inhibit osteoclastogenesis for bone regeneration. This paper is relevant as it addresses osteoporosis, a significant age-related condition, by proposing a localized treatment strategy that could improve bone health and potentially mitigate the effects of aging on bone density.

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