The role of the circadian timing system in sarcopenia in old age: a scoping review.

Francesco Palmese, Ylenia Druda, Rossella Del Toro, Giorgio Bedogni, Marco Domenicali, Alessandro Silvani

Department of Medical and Surgical Sciences, Alma Mater Studiorum Università di Bologna, Ravenna Campus, Ravenna, Italy. [email protected] of Medical and Surgical Sciences, Alma Mater Studiorum Università di Bologna, Ravenna Campus, Ravenna, Italy. [email protected]. · pubmed

Paper

Abstract

Sarcopenia is a progressive and generalized skeletal muscle disorder, involving the accelerated loss of skeletal muscle mass and function, associated with an increased probability of adverse outcomes including falls. The circadian timing system may be involved in molecular pathways leading to sarcopenia in older adults. We aimed to provide an updated and systematic map of the available evidence on the role of the circadian timing system in sarcopenia, specifically related to the aging process.

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Research summary

The paper addresses the circadian timing system's role in sarcopenia, which is a significant age-related condition. While it explores a potential mechanism related to aging, it does not directly tackle the root causes of aging or propose interventions for lifespan extension. The findings may contribute to understanding sarcopenia in older adults, but the overall impact on the field of longevity research is limited.

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