Multi-omics approach reveals TGF-β signaling-driven senescence in periodontium stem cells.

Bo Li, Wei Li, Yueqi Liao, Zhijie Weng, Yafei Chen, Takehito Ouchi, Yi Fan, Zhihe Zhao, Longjiang Li

State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. Electronic address: [email protected] Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

The periodontal ligament (PDL), a dynamic connective tissue that anchors teeth to the alveolar bone, enables tooth retention and facilitates continuous turnover. The integrity of the periodontium is maintained by periodontal ligament stem cells (PDLSCs), whose dysfunction and senescence with age can disrupt tissue homeostasis, hinder injury repair, and lead to tooth loss, ultimately impacting overall health. Transforming growth factor-β1 (TGF-β1) is known for its regenerative properties and as a functional paracrine factor in stem cell therapy, but its precise role in modulating PDLSC activity remains controversial and poorly understood.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that TGF-β signaling drives senescence in periodontal ligament stem cells. This research is relevant as it explores the mechanisms of stem cell senescence, which is a key aspect of aging and tissue regeneration, potentially contributing to understanding age-related decline in tissue function.

Author of this paper? Send a correction.