Characterization of craniofacial tissue aging in genetically diverse HET3 male mice with longevity treatment of 17-alpha estradiol.

Rami Alsabbagh, Leah LaVerde, Emma Chufar, Jake W Willows, Kristy L Townsend, Sarah B Peters

Division Biosciences, College of Dentistry, The Ohio State University, 305 West 12th Avenue, Columbus, OH 43210, USA.Division Biosciences, College of Dentistry, The Ohio State University, 305 West 12th Avenue, Columbus, OH 43210, USA. · pubmed

Paper

Abstract

The objective of our study was to 1) characterize craniofacial tissue aging in the new, genetically diverse HET3 mouse model; and 2) ascertain whether increased longevity with 17-alpha estradiol (17αE2) treatment in male mice also improved the health of these tissues. The HET3 mice are a four-strain cross preferred and recommended by the National Institute of Aging to identify longevity treatments and test their ability to reduce age-related pathologies. Previous reports demonstrated increased longevity in male, but not female, HET3 mice with 17αE2 administration.

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Research summary

The study investigates the effects of 17-alpha estradiol treatment on craniofacial tissue aging in a genetically diverse mouse model. This research is relevant as it explores a potential longevity treatment and its impact on age-related tissue health, contributing to the understanding of aging mechanisms.

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