Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade.

Qu Tian, Erin E Greig, Christos Davatzikos, Bennett A Landman, Susan M Resnick, Luigi Ferrucci

Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA. [email protected] Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA. [email protected]. · pubmed

Paper

Abstract

Impaired muscle mitochondrial oxidative capacity is associated with future cognitive impairment, and higher levels of PET and blood biomarkers of Alzheimer's disease and neurodegeneration. Here, we examine its associations with up to over a decade-long changes in brain atrophy and microstructure. Higher in vivo skeletal muscle oxidative capacity via MR spectroscopy (post-exercise recovery rate, k

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Research summary

The paper investigates the association between skeletal muscle mitochondrial oxidative capacity and brain structure over a decade, which touches on the relationship between physical health and cognitive aging. While it does not directly address the root causes of aging or lifespan extension, it contributes to understanding how muscle health may influence cognitive decline, a relevant aspect of aging research. However, the findings appear to be incremental rather than groundbreaking, limiting its overall impact.

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