FADS1 inhibition protects retinal pigment epithelium cells from ferroptosis in age related macular degeneration.

Ao Zhang, Ting-Ting Wei, Xin Tan, Cheng-Ye Tan, Miao Zhuang, Tian-Hua Xie, Jiping Cai, Yong Yao, Lingpeng Zhu

Department of Ophthalmology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.Department of Ophthalmology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China. · pubmed

Paper

Abstract

Age-related macular degeneration (AMD) is the leading cause of vision loss among the elderly individuals. Retinal pigment epithelium (RPE) ferroptosis is a significant pathogenetic component in AMD. This study aims to elucidate the role and mechanisms of fatty acid desaturase 1 (FADS1) in ferroptosis as well as AMD progression.

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Research summary

FADS1 inhibition protects retinal pigment epithelium cells from ferroptosis in age-related macular degeneration. The study addresses a specific mechanism (ferroptosis) involved in a major age-related disease (AMD), which is relevant to understanding and potentially mitigating aspects of aging.

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