Icariin maintaining TMEM119-positive microglial population improves hippocampus-associated memory in senescent mice in relation to R-3-hydroxybutyric acid metabolism.

Rong Ma, Yuge Zhou, Weifan Huang, Xiaoni Kong

Central Laboratory, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: [email protected] Laboratory, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Epimedium Tourn. ex L. is a traditional Chinese medicine used for thousands of years in China to treat forgetfulness. Icariin is a principal component of the genus Epimedium.

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Research summary

Icariin enhances the population of TMEM119-positive microglia, which in turn improves memory in senescent mice through mechanisms related to R-3-hydroxybutyric acid metabolism. The study addresses the role of microglial health in cognitive function, which is relevant to understanding and potentially mitigating age-related cognitive decline.

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