Effects of Aging on Glucose and Lipid Metabolism in Mice.

Evan C Lien, Ngoc Vu, Anna M Westermark, Laura V Danai, Allison N Lau, Yetiş Gültekin, Matthew A Kukurugya, Bryson D Bennett, Matthew G Vander Heiden

Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, Michigan, USA.Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, Michigan, USA. · pubmed

Paper

Abstract

Aging is accompanied by multiple molecular changes that contribute to aging associated pathologies, such as accumulation of cellular damage and mitochondrial dysfunction. Tissue metabolism can also change with age, in part, because mitochondria are central to cellular metabolism. Moreover, the cofactor NAD

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the effects of aging on glucose and lipid metabolism, which are important aspects of cellular metabolism and aging-related changes. While it addresses metabolic alterations associated with aging, it does not appear to focus on root causes of aging or mechanisms for lifespan extension. The findings may contribute to understanding age-related metabolic disorders, but they do not present a significant advancement in the field of longevity research. Thus, the impact is rated as a solid but limited contribution.

Author of this paper? Send a correction.