Centenarians-the way to healthy vascular ageing and longevity: a review from VascAgeNet.

Sabrina Summer, Maria Borrell-Pages, Rosa-Maria Bruno, Rachel E Climie, Konstantina Dipla, Aysenur Dogan, Kseniia Eruslanova, Emil Fraenkel, Francesco Mattace-Raso, Christopher J A Pugh, Keith D Rochfort, Mark Ross, Lynn Roth, Arno Schmidt-Trucksäss, Dennis Schwarz, James Shadiow, Yahya Sohrabi, Jannik Sonnenberg, Olga Tura-Ceide, Bilge Guvenc Tuna, Josep Julve, Soner Dogan

Department for Biomedical Research, University for Continuing Education Krems, Krems, Austria. · pubmed

Paper

Abstract

The prevalence of centenarians, people who lived 100 years and longer, is steadily growing in the last decades. This exceptional longevity is based on multifaceted processes influenced by a combination of intrinsic and extrinsic factors such as sex, (epi-)genetic factors, gut microbiota, cellular metabolism, exposure to oxidative stress, immune status, cardiovascular risk factors, environmental factors, and lifestyle behavior. Epidemiologically, the incidence rate of cardiovascular diseases is reduced in healthy centenarians along with late onset of age-related diseases compared with the general aged population. Understanding the mechanisms that affect vascular ageing in centenarians and the underlying factors could offer valuable insights for developing strategies to improve overall healthy life span in the elderly. This review discusses these key factors influencing vascular ageing and how their modulation could foster healthy longevity.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses the factors influencing vascular aging in centenarians, which is directly related to understanding the mechanisms of aging and longevity. It aims to provide insights that could lead to strategies for improving healthy lifespan in the elderly, aligning with the goals of longevity research. However, while it presents solid research, the findings appear to be more of a review of existing knowledge rather than presenting novel insights or breakthroughs, thus limiting its overall impact.

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