The mitochondrial and cytoplasmic superoxide anion imbalance trigger the expression of certain cellular aging markers in HaCaT keratinocytes.

Nathalia Cardoso de Afonso Bonotto, Ivana Beatrice Mânica da Cruz, Bárbara Osmarin Turra, Ana Laura Kerkhoff Escher, Fernanda Dos Santos Trombini, João Arthur B Zimmermann, Verônica Farina Azzolin, Micheli Mainardi Pillat, Euler Esteves Ribeiro-Filho, Fernanda Barbisan

Postgraduate Program in Pharmacology, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil.Postgraduate Program in Pharmacology, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil. · pubmed

Paper

Abstract

In cells, the term "cellular aging" represents a collection of biological changes that can precede the proliferative senescence states. Cells more resistant to proliferative senescence, such as the ones found in the basal layer of the epidermis, may also exhibit these aging patterns. Therefore, cellular aging events could be induced by endogenous signals named here as cellular aging triggers (CATs) components. The superoxide anion (O

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Research summary

The paper investigates the role of superoxide anion imbalance in triggering cellular aging markers in keratinocytes, which is relevant to understanding the mechanisms of aging. However, the findings appear to be more focused on cellular responses rather than addressing root causes of aging or proposing interventions for lifespan extension. Thus, while it contributes to the field, its impact is limited.

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