Multi-Night Electroencephalography Reveals Positive Association Between Sleep Efficiency and Hippocampal Subfield and Entorhinal Cortex Volumes in Healthy Aging.

Attila Keresztes, Éva M Bankó, Noémi Báthori, Vivien Tomacsek, Virág Anna Varga, Ádám Nárai, Zsuzsanna Nemecz, Ádám Dénes, Viktor Gál, Petra Hermann, Péter Simor, Zoltán Vidnyánszky

Brain Imaging Centre, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary. · pubmed

Paper

Abstract

Age-related atrophy of the human hippocampus and the enthorinal cortex starts accelerating at around age 60. Due to the contributions of these regions to many cognitive functions seamlessly used in everyday life, this can heavily impact the lives of elderly people. The hippocampus is not a unitary structure, and mechanisms of its age-related decline appear to differentially affect its subfields. Human and animal studies have suggested that altered sleep is associated with hippocampal atrophy. Yet, we know little about subfield specific effects of altered sleep in healthy aging and their effect on cognition. Here, in a sample of 118 older middle-aged and older adults (M

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Research summary

The paper investigates the relationship between sleep efficiency and the volumes of specific hippocampal subfields and the entorhinal cortex in the context of healthy aging. While it touches on important aspects of cognitive function and brain structure in aging, it primarily focuses on associations rather than addressing root causes of aging or mechanisms that could lead to lifespan extension. The findings may contribute to understanding cognitive decline in aging, but they do not present a significant advancement in the field of longevity research.

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