DNA aptamers that modulate biological activity of model neurons.

Jenelle Rolli, Keenan Pearson, Brandon Wilbanks, Sybil C L Hrstka, Andrew P Minotti, Lorenz Studer, Arthur E Warrington, Nathan P Staff, L James Maher

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA. · pubmed

Paper

Abstract

There is an urgent need for agents that promote health and regeneration of cells and tissues, specifically to treat diseases of the aging nervous system. Age-associated nervous system degeneration and various diseases are driven by many different biochemical stresses, often making it difficult to target any one disease cause. Our laboratory has previously identified DNA aptamers with apparent regenerative properties in murine models of multiple sclerosis by selecting aptamers that bind oligodendrocyte membrane preparations. Here, we selected from vast libraries of molecules (∼10

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses the use of DNA aptamers to modulate biological activity in model neurons, which is relevant to addressing age-associated degeneration in the nervous system. However, it primarily focuses on a specific treatment approach rather than tackling the root causes of aging or promoting lifespan extension. The findings may contribute to understanding regenerative mechanisms but do not represent a significant breakthrough in longevity research. Thus, the impact is rated as a solid but limited contribution.

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