Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress tolerance.
Abstract
Artemisia argyi Lévl. et Vant. (A. argyi) leaf possesses various health promoting functions contributed by its main bioactive flavonoids. In this study, the anti-aging effect and mechanism of Artemisia argyi leaf extract (AALE) were identified using Caenorhabditis elegans (C. elegans) as a model. The results showed that the AALE promoted the lifespan and stress resistance of C. elegans. It was found that the AALE boosted the expression of oxidative stress-related proteins by regulating the insulin/ IGF-1 signaling (IIS) pathway, which then activated the transcription factors DAF-16/FOXO. The results of RNA-sequence analysis indicated that the changes of genes in nematodes treated with AALE were associated with the responses against oxidative stress, cell maturation, and immune reaction, and stress. The positive results suggest that Artemisia argyi leaf could have the robust benefits for improving healthy aging as well as preventing aging-related diseases in the human body.
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Research summary
The paper investigates the effects of Artemisia argyi leaf extract on lifespan and stress tolerance in a model organism, C. elegans, which is relevant to longevity research. It explores the molecular mechanisms involved, particularly the regulation of the insulin/IGF-1 signaling pathway and oxidative stress responses, which are important factors in aging. However, while the findings contribute to understanding the potential benefits of this herb for healthy aging, the study appears to be an incremental advance rather than a significant breakthrough, limiting its overall impact.
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