PD-1-Enhanced Treg Cell Senescence in Advanced Maternal Age.

Guang-Shun Gong, Yu-Jing Zhang, Xiao-Hui Hu, Xin-Xiu Lin, Ai-Hua Liao

Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P. R. China.Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P. R. China. · pubmed

Paper

Abstract

Senescence occurs earlier in the immune system than in solid organs as age increases. Regulatory T (Treg) cells are among the first cells to exhibit signs of aging. However, whether advanced-age pregnancy involves Treg cell aging remains unclear. This study demonstrated that the aging of women is accompanied by aging Treg cells and that PD-1 regulates Treg cell aging. The transfer of young Treg cells can improve the pregnancy outcomes of reproductive-aged mice by reducing the level of IFN-γ, a proinflammatory cytokine secreted by Treg cells in aged mice. Transferring α-PD-1 mAb-treated aged Treg cells increases the level of IL-10, an anti-inflammatory cytokine secreted by Treg cells in reproductive-aged mice. Collectively, these findings suggest a potential therapeutic strategy for preventing adverse pregnancy outcomes in older women.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper addresses the aging of Treg cells in the context of advanced maternal age, which is relevant to understanding immune system senescence as a component of aging. However, while it suggests a potential therapeutic strategy for improving pregnancy outcomes, it does not directly tackle the root causes of aging or lifespan extension. The findings are interesting but represent a solid research contribution with limited broader implications for the field of longevity.

Author of this paper? Send a correction.