Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy.

Ashwini Vinod Shete, Pallavi Shidhaye, Amrita Rao, Nikita Bhawari, Supriya Deshpande, Jyoti Sawant, Rajani Bagul, Ujjwala Ghule, Sunita Kumbhar, Manisha Ghate

ICMR-National Institute of Translational Virology and AIDS Research (formerly ICMR-National AIDS Research Institute), 73, G block, MIDC, Bhosari, Pune, 411026, India. [email protected]. · pubmed

Paper

Abstract

People living with HIV (PLHIV) demonstrate accelerated aging and immunosenescence in spite of immune-restoration following long-term antiretroviral treatment (ART). Low level inflammation leading to inflammaging plays an important role in mediating premature immunosenescence. Ongoing viral replication, antiretrovirals and subclinical infections with the common viruses like Cytomegalovirus (CMV) are known to induce inflammaging. However such data is scarce in India where persistent low level inflammation is common in general population due to various subclinical infections. Hence we conducted a study to determine the extent of immunosenescence in asymptomatic PLHIV on long term ART in comparison with their age-matched controls.

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Research summary

The paper investigates the associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV, which is pertinent to understanding the mechanisms of aging and inflammation in a specific population. However, while it contributes to the knowledge of immunosenescence, it does not address the root causes of aging or propose solutions for lifespan extension, limiting its overall impact in the broader field of longevity research.

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