Effects of feeding the medium-chain triacylglycerol on GLP-1 secretion in aged Brd4-heterozygous mice, which are a mouse model of aging.

Musashi Kawamura, Natsuyo Hariya, Shiori Ishiyama, Yuji Tanaka, Keiko Ozato, Kazuki Mochizuki

Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Kofu, Yamanashi, Japan; Department of Local Produce and Food Sciences, Laboratory of Food and Nutritional Sciences, Faculty of Life and Environmental Sciences, University of Yamanashi, Kofu, Yamanashi, Japan. · pubmed

Paper

Abstract

Gastrointestinal hormones, such as glucagon-like peptide 1 (GLP-1), gastric inhibitory polypeptide, and peptide YY (PYY) are important for reducing malnutrition at older ages because they are related to assimilation and feeding behavior. Medium-chain triacylglycerol (MCT) ameliorates metabolic symptoms and frailty in adults; however, whether it has the same effect in old age is unknown. To address this, we examined the changes in insulin and gastrointestinal hormones in aged Brd4 (+/-) mice exhibiting symptoms of old age.

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Research summary

The paper investigates the effects of medium-chain triacylglycerol on GLP-1 secretion in a mouse model of aging, which is relevant to understanding metabolic changes associated with aging. However, the focus on gastrointestinal hormones and their role in malnutrition does not directly address the root causes of aging or lifespan extension. The findings may contribute to the understanding of age-related metabolic issues but are unlikely to have a significant impact on the broader field of longevity research.

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