A unique inflammaging profile generated by T cells from people with obesity is metformin resistant.

S SantaCruz-Calvo, S Saraswat, G H Kalantar, E Zukowski, H Marszalkowski, A Javidan, F Gholamrezaeinejad, L P Bharath, P A Kern, X D Zhang, B S Nikolajczyk

Department of Pharmacology & Nutritional Sciences, Diabetes and Obesity Research Priority Area, University of Kentucky, Lexington, KY, USA. · pubmed

Paper

Abstract

The alarmingly high prevalence of obesity in older adults coupled with the negative health effects of chronic inflammation in both obesity and aging highlight the importance of studies investigating the impacts of obesity on age-related inflammation. Since shifts in peripheral T-cell metabolism and function drive systemic inflammation in both obesity and aging, we hypothesize that obesity impacts the Th17-dominated inflammaging profile we identified in lean subjects and thus modifies the anti-inflammatory effects of geroprotective drugs like metformin. New cytokine profiling data showed that CD4

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Research summary

The paper investigates the relationship between obesity, chronic inflammation, and T-cell function, which are important factors in the context of aging and age-related diseases. However, while it addresses a relevant aspect of inflammaging and the potential resistance to geroprotective drugs like metformin, the findings appear to be more incremental rather than groundbreaking. The study contributes to understanding the mechanisms involved but does not present a transformative approach to addressing the root causes of aging or significantly advancing the field.

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