Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 1.

Zhiyi Fang, Linghuan Wang, Yabin Wang, Yan Ma, Yan Fang, Weiwei Zhang, Ruihua Cao, Yingjie Zhang, Hui Li, Sijia Chen, Lei Tian, Xiaoying Shen, Feng Cao

School of Medicine, Nankai University, 94 Weijin Road, Tianjin 30071, China; Institude of Chinese PLA Geriatric Medicine, The Second Medical Centre, Chinese PLA General Hospital & National Clinical Research Center for Geriatric Diseases, Beijing 100853, China.School of Medicine, Nankai University, 94 Weijin Road, Tianjin 30071, China; Institude of Chinese PLA Geriatric Medicine, The Second Medical Centre, Chinese PLA General Hospital & National Clinical Research Center for Geriatric Diseases, Beijing 100853, China. · pubmed

Paper

Abstract

The senescence of smooth muscle is one of the independent risk factors in atherosclerosis progression in which the vascular inflammation plays an important role on vascular dysfunction. This study is designed to explore the novel vascular aging biomarkers and screen the potential molecular interventional targets through bioinformatic analysis.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper addresses vascular aging, which is a significant aspect of the aging process and its associated diseases. It explores the protective effects of narciclasine on vascular aging through mechanisms involving inflammation and metabolism, indicating a focus on underlying biological processes rather than merely treating symptoms. However, while the research is solid, it appears to be an incremental advance rather than a groundbreaking discovery, limiting its overall impact on the field of longevity research.

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