Therapeutic potential of adult stem cells-derived mitochondria transfer combined with curcumin administration into ARPE-19 cells in age-related macular degeneration model.

Kamil Can Kılıç, Gökhan Duruksu, Ahmet Öztürk, Selenay Furat Rençber, Buket Kılıç, Yusufhan Yazır

Department of Stem Cell, Institute of Health Sciences, Kocaeli University, Kocaeli, Turkey; Center for Stem Cell and Gene Therapies Research and Practice, Kocaeli University, Kocaeli, Turkey; Department of Histology and Embryology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. · pubmed

Paper

Abstract

Mitochondria transfer from human Wharton's Jelly-derived mesenchymal stem cells (hWJ-MSCs-mt) and human endometrium-derived mesenchymal stem cells (hE-MSCs-mt), along with curcumin, were explored as potential treatments for age-related macular degeneration (AMD) caused by mitochondrial inefficiency, using a retinal model to assess impacts of curcumin and hWJ-MSCs-mt or hE-MSCs-mt on AMD.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper addresses a potential therapeutic approach for age-related macular degeneration (AMD) by exploring mitochondrial transfer and curcumin administration, which are linked to mitochondrial dysfunction—a known contributor to aging. However, while it touches on a significant aspect of aging, the focus remains on treating a specific age-related disease rather than addressing the root causes of aging itself. Thus, it represents solid research but with limited broader impact on the field of longevity.

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