Age-related lung changes linked to altered lysosomal protease profile, histology, and ultrastructure.

Mohammed Aufy, Mahmoud Abd-Elkareem, Medina Mustafic, Mostafa A Abdel-Maksoud, Ali Hakamy, Veronika Baresova, Akram A Alfuraydi, Mahmoud Ashry, Jana Lubec, Ayman S Amer, Christian R Studenik, Ahmed M Hussein, Mohamed H Kotob

Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria. · pubmed

Paper

Abstract

The aging process is intricately linked to alterations in cellular and tissue structures, with the respiratory system being particularly susceptible to age-related changes. Therefore, this study aimed to profile the activity of proteases using activity-based probes in lung tissues of old and young rats, focusing on the expression levels of different, in particular cathepsins G and X and matrix Metalloproteinases (MMPs). Additionally, the impact on extracellular matrix (ECM) components, particularly fibronectin, in relation to age-related histological and ultrastructural changes in lung tissues was investigated.

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Research summary

The paper investigates age-related changes in lung tissues, focusing on protease activity and extracellular matrix components, which are relevant to understanding the biological mechanisms of aging. However, the study appears to be more descriptive and focused on specific changes rather than addressing root causes of aging or proposing interventions for lifespan extension. Thus, while it contributes to the field of aging research, its impact is limited.

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