Dietary methionine supplementation improves cognitive dysfunction associated with transsulfuration pathway upregulation in subacute aging mice.

Yuncong Xu, Yuhui Yang, Yonghui Shi, Bowen Li, Yanli Xie, Guowei Le

Henan Key Laboratory of cereal and Oil Food Safety Inspection and Control, College of Food Science and Engineering, Henan University of Technology, Zhengzhou, Henan, China.Henan Key Laboratory of cereal and Oil Food Safety Inspection and Control, College of Food Science and Engineering, Henan University of Technology, Zhengzhou, Henan, China. · pubmed

Paper

Abstract

To explore the effects of methionine (Met) supplementation on cognitive dysfunction and the associated mechanisms in aging mice. The mice were administrated 0.15 g/kg/day D-galactose subcutaneously and fed a normal (0.86% Met) or a Met-supplemented diet (1.72% Met) for 11 weeks. Behavioral experiments were conducted, and we measured the plasma metabolite levels, hippocampal and plasma redox and inflammatory states, and hippocampal transsulfuration pathway-related parameters. Met supplementation prevented aging-induced anxiety and cognitive deficiencies, and normalized the plasma levels of multiple systemic metabolites (e.g., betaine, taurine, and choline). Furthermore, dietary Met supplementation abolished oxidative stress and inflammation, selectively modulated the expression of multiple cognition-related genes and proteins, and increased flux via the transsulfuration pathway in the hippocampi of aging mice, with significant increase in H

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Research summary

The paper investigates the effects of dietary methionine supplementation on cognitive dysfunction in aging mice, which is relevant to understanding mechanisms that may influence aging and cognitive decline. However, the findings appear to be an incremental advance rather than a significant breakthrough in the field of longevity research. The focus on dietary supplementation and its effects on specific pathways does contribute to the broader understanding of aging, but the implications for lifespan extension or addressing root causes of aging are limited.

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