Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing.

Qi Qu, Yan Chen, Yu Wang, Weiche Wang, Shating Long, Heng-Ye Yang, Jianfeng Wu, Mengqi Li, Xiao Tian, Xiaoyan Wei, Yan-Hui Liu, Shengrong Xu, Jinye Xiong, Chunyan Yang, Zhenhua Wu, Xi Huang, Changchuan Xie, Yaying Wu, Zheni Xu, Cixiong Zhang, Baoding Zhang, Jin-Wei Feng, Junjie Chen, Yuanji Feng, Huapan Fang, Liyun Lin, Z K Xie, Beibei Sun, Huayu Tian, Yong Yu, Hai-Long Piao, Xiao-Song Xie, Xianming Deng, Chen-Song Zhang, Sheng-Cai Lin

State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China. · pubmed

Paper

Abstract

Lithocholic acid (LCA) is accumulated in mammals during calorie restriction and it can activate AMP-activated protein kinase (AMPK) to slow down ageing

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses the role of lithocholic acid in activating AMPK, which is associated with metabolic regulation and longevity. While it touches on mechanisms that could influence aging, the findings appear to be incremental rather than groundbreaking. The activation of sirtuins and AMPK is known in the field, and while this study may contribute to understanding these pathways, it does not present a major breakthrough or novel approach to directly addressing the root causes of aging.

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