Lithocholic acid phenocopies anti-ageing effects of calorie restriction.

Qi Qu, Yan Chen, Yu Wang, Shating Long, Weiche Wang, Heng-Ye Yang, Mengqi Li, Xiao Tian, Xiaoyan Wei, Yan-Hui Liu, Shengrong Xu, Cixiong Zhang, Mingxia Zhu, Sin Man Lam, Jianfeng Wu, Chuyu Yun, Junjie Chen, Shengye Xue, Baoding Zhang, Zhong-Zheng Zheng, Hai-Long Piao, Changtao Jiang, Hao Guo, Guanghou Shui, Xianming Deng, Chen-Song Zhang, Sheng-Cai Lin

State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China. · pubmed

Paper

Abstract

Calorie restriction (CR) is a dietary intervention used to promote health and longevity

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates lithocholic acid as a phenocopy of calorie restriction, which is directly related to mechanisms of aging and longevity. While the findings may contribute to understanding the biological pathways involved in aging, the impact appears to be solid but limited, as it may not provide groundbreaking insights or solutions to the root causes of aging.

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