Plasma extracellular vesicles carry immune system-related peptides that predict human longevity.

Xin Zhang, Sisi Ma, Syeda Iffat Naz, Erik J Soderblom, Constantin Aliferis, Virginia Byers Kraus

Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 27701, USA. [email protected] Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 27701, USA. [email protected]. · pubmed

Paper

Abstract

Extracellular vesicles (EVs) play crucial roles in aging. In this National Institutes on Aging-funded study, we sought to identify circulating extracellular vesicle (EV) biomarkers indicative of longevity. The plasma EV proteome of 48 older adults (mean age 77.2 ± 1.7 years [range 72-80]; 50% female, 50% Black, 50% < 2-year survival, 50% ≥ 10-year survival) was analyzed by high-resolution mass spectrometry and flow cytometry. The ability of EV peptides to predict longevity was evaluated in discovery (n = 32) and validation (n = 16) datasets with areas under receiver operating characteristic curves (AUCs). Longevity-associated large EV (LEV) plasma subpopulations were mainly related to immune cells (HLA-ABC

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Research summary

The paper investigates the role of plasma extracellular vesicles as biomarkers for predicting human longevity, which aligns with the study of aging and potential mechanisms related to lifespan extension. While the findings contribute to the understanding of longevity-related biomarkers, the study's sample size and focus on immune system-related peptides suggest it offers solid research but with limited immediate impact on the broader field of longevity research.

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