Inter-organ communication is a critical machinery to regulate metabolism and aging.
Abstract
Inter-organ communication (IOC) is a complex mechanism involved in maintaining metabolic homeostasis and healthy aging. Dysregulation of distinct forms of IOC is linked to metabolic derangements and age-related pathologies, implicating these processes as a potential target for therapeutic intervention to promote healthy aging. In this review, we delve into IOC mediated by hormonal signaling, circulating factors, organelle signaling, and neuronal networks and examine their roles in regulating metabolism and aging. Given the role of the hypothalamus as a high-order control center for aging and longevity, we particularly emphasize the importance of its communication with peripheral organs and pave the way for a better understanding of this critical machinery in metabolism and aging.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper discusses inter-organ communication as a mechanism that regulates metabolism and aging, which is directly relevant to longevity research. It highlights the potential for therapeutic interventions aimed at promoting healthy aging, indicating a focus on addressing root causes rather than merely treating symptoms. However, while the review provides a solid overview of the topic, it does not present novel experimental findings or groundbreaking insights that would significantly advance the field, thus earning a moderate impact score.
Author of this paper? Send a correction.