A Binary siRNA-Loaded Tetrahedral DNA Nanobox for Synergetic Anti-Aging Therapy.

Ziqi Yue, Yichen Yang, Lulingxiao Nie, Yuezhang Sun, Qi Wang, Yunfeng Lin, Yang Gao, Xiaoxiao Cai

State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China.State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China. · pubmed

Paper

Abstract

Extensive accumulation of senescent cells contributes to organismal aging, and slowing down the process of cellular senescence may ameliorate age-related pathologies. Targeted inhibition of the mechanistic target of rapamycin complex 1 (mTORC1) is found to suppress the conversion of cells to senescence. The regulatory-associated protein of mTOR (Raptor), a key component of mTORC1, has been implicated as important in the aging process, and its druggability deserves to be investigated. Due to high efficiency and high convenience in drug construction, siRNA shows great potential in silencing Raptor expression via RNA interfering therapy. Here, we developed a functionalized anti-aging nanoplatform based on tetrahedral DNA nanostructures (TDNs) encapsulating siRNA targeting Raptor for synergistic anti-aging therapy, named siR-TDN

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper addresses a significant aspect of aging by targeting cellular senescence through the inhibition of mTORC1, which is directly related to the aging process. The development of a novel nanoplatform for delivering siRNA to silence Raptor expression represents a solid research advance in the field of anti-aging therapies. However, while the approach is innovative, it may not yet demonstrate the transformative potential needed for a higher impact score, as it primarily builds on existing knowledge rather than presenting a groundbreaking new concept.

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