Proteomic Markers of Aging and Longevity: A Systematic Review.
Abstract
This article provides a systematic review of research conducted on the proteomic composition of blood as part of a complex biological age estimation. We performed a comprehensive analysis of 17 publicly available datasets and compiled an integral list of proteins. These proteins were sorted based on their detection probability using mass spectrometry in human plasma. We propose this list as a basis for creating a panel of peptides and quantifying the content of selected proteins in the format of a proteomic aging clock. The selected proteins are especially notable for their roles in inflammatory processes and lipid metabolism. Our findings suggest, for the first time, that proteins associated with systemic disorders, including those approved by the FDA for clinical use, could serve as potential markers of aging.
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Research summary
The paper systematically reviews the proteomic markers associated with aging, which is directly relevant to understanding the biological processes of aging and potential longevity interventions. While the findings contribute to the field by proposing a panel of proteins that could serve as markers of aging, the impact appears to be limited as it primarily compiles existing data rather than presenting novel experimental results or groundbreaking insights.
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